Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation

Inflammation is considered a mechanistic driver of Alzheimer's disease, thought to increase tau phosphorylation, the first step to the formation of neurofibrillary tangles (NFTs). To further understand how inflammation impacts the development of tau pathology, we used (hTau) mice, which express...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Barron, Matthew R., Gartlon, Jane, Dawson, Lee A., Atkinson, Peter J., Pardon, Marie-Christine
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066213/
https://ncbi.nlm.nih.gov/pubmed/32194553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00293
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