Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation

Inflammation is considered a mechanistic driver of Alzheimer's disease, thought to increase tau phosphorylation, the first step to the formation of neurofibrillary tangles (NFTs). To further understand how inflammation impacts the development of tau pathology, we used (hTau) mice, which express...

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Bibliografische gegevens
Gepubliceerd in:Front Immunol
Hoofdauteurs: Barron, Matthew R., Gartlon, Jane, Dawson, Lee A., Atkinson, Peter J., Pardon, Marie-Christine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066213/
https://ncbi.nlm.nih.gov/pubmed/32194553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00293
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