Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection

Major Histocompatibility Complex (MHC) class I molecules selectively bind peptides for presentation to cytotoxic T cells. The peptide-free state of these molecules is not well understood. Here, we characterize a disulfide-stabilized version of the human class I molecule HLA-A*02:01 that is stable in...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Anjanappa, Raghavendra, Garcia-Alai, Maria, Kopicki, Janine-Denise, Lockhauserbäumer, Julia, Aboelmagd, Mohamed, Hinrichs, Janina, Nemtanu, Ioana Maria, Uetrecht, Charlotte, Zacharias, Martin, Springer, Sebastian, Meijers, Rob
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066147/
https://ncbi.nlm.nih.gov/pubmed/32161266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14862-4
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