Defective Interferon Gamma Production by Tumor-Specific CD8(+) T Cells Is Associated With 5′Methylcytosine-Guanine Hypermethylation of Interferon Gamma Promoter

Interferon gamma (IFNγ) supports effector responses of CD8(+) cytotoxic T lymphocytes (CTLs) and is a surrogate marker for detection of antigen-specific T cells. Here, we show that tumor-specific CTL clones have impaired IFNγ expression and production upon activation. Assessment of the relationship...

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Udgivet i:Front Immunol
Main Authors: Abd Hamid, Megat, Yao, Xuan, Waugh, Craig, Rosendo-Machado, Samara, Li, Chris, Rostron, Timothy, Frankland, John, Peng, Yanchun, Dong, Tao
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066077/
https://ncbi.nlm.nih.gov/pubmed/32194559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00310
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