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Defective Interferon Gamma Production by Tumor-Specific CD8(+) T Cells Is Associated With 5′Methylcytosine-Guanine Hypermethylation of Interferon Gamma Promoter
Interferon gamma (IFNγ) supports effector responses of CD8(+) cytotoxic T lymphocytes (CTLs) and is a surrogate marker for detection of antigen-specific T cells. Here, we show that tumor-specific CTL clones have impaired IFNγ expression and production upon activation. Assessment of the relationship...
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| Pubblicato in: | Front Immunol |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7066077/ https://ncbi.nlm.nih.gov/pubmed/32194559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00310 |
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