Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome

Methylated cytosine is an effector of epigenetic gene regulation. In the brain, Dnmt3a is the sole ‘writer’ of atypical non-CpG methylation (mCH), and MeCP2 is the only known ‘reader’ for mCH. We asked if MeCP2 is the sole reader for Dnmt3a dependent methylation by comparing mice lacking either prot...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Lavery, Laura A, Ure, Kerstin, Wan, Ying-Wooi, Luo, Chongyuan, Trostle, Alexander J, Wang, Wei, Jin, Haijing, Lopez, Joanna, Lucero, Jacinta, Durham, Mark A, Castanon, Rosa, Nery, Joseph R, Liu, Zhandong, Goodell, Margaret, Ecker, Joseph R, Behrens, M Margarita, Zoghbi, Huda Y
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2020
Ämnen:
Chromosomes and Gene Expression
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065908/
https://ncbi.nlm.nih.gov/pubmed/32159514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52981
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