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The distinct methylation landscape of maturing neurons and its role in Rett Syndrome Pathogenesis

Rett syndrome (RTT) is one of the most common causes of intellectual and developmental disabilities in girls, and is caused by mutations in the gene encoding methyl-CpG binding protein 2 (MECP2). Here we will review our current understanding of RTT, the landscape of pathogenic mutations and function...

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Detalhes bibliográficos
Publicado no:Curr Opin Neurobiol
Main Authors: Lavery, Laura A., Zoghbi, Huda Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892602/
https://ncbi.nlm.nih.gov/pubmed/31542590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.conb.2019.08.001
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