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Oxidative DNA-protein Crosslinks Formed in Mammalian Cells by Abasic Site Lyases Involved in DNA Repair
Free radical attack on C1′ of deoxyribose forms the oxidized abasic (AP) site 2-deoxyribonolactone (dL). In vitro, dL traps the major base excision DNA repair enzyme DNA polymerase beta (Polβ) in covalent DNA-protein crosslinks (DPC) via the enzyme’s N-terminal lyase activity acting on 5′-deoxyribos...
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| izdano v: | DNA Repair (Amst) |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7065521/ https://ncbi.nlm.nih.gov/pubmed/31945542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2019.102773 |
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