T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

BACKGROUND: Chimeric antigen receptor (CAR) modified T cells targeting CD19 have shown activity in case series of patients with acute and chronic lymphocytic leukaemia and B-cell lymphomas, but feasibility, toxicity, and response rates of consecutively enrolled patients treated with a consistent reg...

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Detalhes bibliográficos
Publicado no:Lancet
Main Authors: Lee, Daniel W, Kochenderfer, James N, Stetler-Stevenson, Maryalice, Cui, Yongzhi K, Delbrook, Cindy, Feldman, Steven A, Fry, Terry J, Orentas, Rimas, Sabatino, Marianna, Shah, Nirali N, Steinberg, Seth M, Stroncek, Dave, Tschernia, Nick, Yuan, Constance, Zhang, Hua, Zhang, Ling, Rosenberg, Steven A, Wayne, Alan S, Mackall, Crystal L
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065359/
https://ncbi.nlm.nih.gov/pubmed/25319501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(14)61403-3
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