Programmable CRISPR interference for gene silencing using Cas13a in mosquitoes

In the CRISPR-Cas systems, Cas13a is an RNA-guided RNA nuclease specifically targeting single strand RNA. We developed a Cas13a mediated CRISPR interference tool to target mRNA for gene silencing in mosquitoes. A Cas13a expressing plasmid was delivered to mosquitoes by intrathoracic injection, and C...

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Bibliografske podrobnosti
izdano v:J Genomics
Main Authors: Kulkarni, Aditi, Yu, Wanqin, Moon, Alex S., Pandey, Ashmita, Hanley, Kathryn A., Xu, Jiannong
Format: Artigo
Jezik:Inglês
Izdano: Ivyspring International Publisher 2020
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064736/
https://ncbi.nlm.nih.gov/pubmed/32190127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jgen.43928
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