Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice

The DNA damage response after kidney injury induces cell cycle arrest in renal tubular epithelial cells, resulting in the secretion of pro-fibrotic cytokines, thereby promoting interstitial fibrosis in a paracrine manner. Phosphorylation of ataxia-telangiectasia mutated (ATM) is the initial step in...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Uehara, Masahiro, Kusaba, Tetsuro, Ida, Tomoharu, Nakai, Kunihiro, Nakata, Tomohiro, Tomita, Aya, Watanabe-Uehara, Noriko, Ikeda, Kisho, Kitani, Takashi, Yamashita, Noriyuki, Kirita, Yuhei, Matoba, Satoaki, Humphreys, Benjamin D., Tamagaki, Keiichi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064514/
https://ncbi.nlm.nih.gov/pubmed/32157166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61456-7
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