Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice

The DNA damage response after kidney injury induces cell cycle arrest in renal tubular epithelial cells, resulting in the secretion of pro-fibrotic cytokines, thereby promoting interstitial fibrosis in a paracrine manner. Phosphorylation of ataxia-telangiectasia mutated (ATM) is the initial step in...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Uehara, Masahiro, Kusaba, Tetsuro, Ida, Tomoharu, Nakai, Kunihiro, Nakata, Tomohiro, Tomita, Aya, Watanabe-Uehara, Noriko, Ikeda, Kisho, Kitani, Takashi, Yamashita, Noriyuki, Kirita, Yuhei, Matoba, Satoaki, Humphreys, Benjamin D., Tamagaki, Keiichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064514/
https://ncbi.nlm.nih.gov/pubmed/32157166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61456-7
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados