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Arteriovenous Malformation MAP2K1 Mutation Causes Local Cartilage Overgrowth by a Cell-Non Autonomous Mechanism

Extracranial arteriovenous malformation (AVM) is most commonly caused by MAP2K1 mutations in the endothelial cell. The purpose of this study was to determine if local tissue overgrowth associated with AVM is caused by direct or indirect effects of the MAP2K1 mutation (i.e., cell-autonomous or cell-n...

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Publicat a:Sci Rep
Autors principals: Konczyk, Dennis J., Goss, Jeremy A., Smits, Patrick J., Sudduth, Christopher L., Al-Ibraheemi, Alyaa, Greene, Arin K.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064492/
https://ncbi.nlm.nih.gov/pubmed/32157142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61444-x
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