Selective Janus Kinase 1 Inhibition Is a Promising Therapeutic Approach for Lupus Erythematosus Skin Lesions

BACKGROUND: Cutaneous lupus erythematosus (CLE) is an interferon (IFN) -driven autoimmune skin disease characterized by an extensive cytotoxic lesional inflammation with activation of different innate immune pathways. Aim of our study was to investigate the specific role of Janus kinase 1 (JAK1) act...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Fetter, Tanja, Smith, Paul, Guel, Tugce, Braegelmann, Christine, Bieber, Thomas, Wenzel, Joerg
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064060/
https://ncbi.nlm.nih.gov/pubmed/32194562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00344
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