Impact of Inaccurate Documentation of Sampling and Infusion Time in Model-Informed Precision Dosing

BACKGROUND: Routine clinical TDM data is often used to develop population pharmacokinetic (PK) models, which are applied in turn for model-informed precision dosing. The impact of uncertainty in documented sampling and infusion times in population PK modeling and model-informed precision dosing have...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Alihodzic, Dzenefa, Broeker, Astrid, Baehr, Michael, Kluge, Stefan, Langebrake, Claudia, Wicha, Sebastian Georg
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063976/
https://ncbi.nlm.nih.gov/pubmed/32194411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00172
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