Fibroblast-Derived CXCL12 Promotes Breast Cancer Metastasis by Facilitating Tumor Cell Intravasation

The chemokine CXCL12 has been shown to regulate breast tumor growth, however, its mechanism in initiating distant metastasis is not well understood. Here, we generated a novel conditional allele of Cxcl12 in mice and used a fibroblast-specific Cre transgene along with various mammary tumor models to...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncogene
Päätekijät: Ahirwar, Dinesh K., Nasser, Mohd W., Ouseph, Madhu M., Elbaz, Mohamad, Cuitiño, Maria C., Kladney, Raleigh D., Varikuti, Sanjay, Kaul, Kirti, Satoskar, Abhay R., Ramaswamy, Bhuvaneswari, Zhang, Xiaoli, Ostrowski, Michael C., Leone, Gustavo, Ganju, Ramesh K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063845/
https://ncbi.nlm.nih.gov/pubmed/29720724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0263-7
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