Fibroblast-Derived CXCL12 Promotes Breast Cancer Metastasis by Facilitating Tumor Cell Intravasation

The chemokine CXCL12 has been shown to regulate breast tumor growth, however, its mechanism in initiating distant metastasis is not well understood. Here, we generated a novel conditional allele of Cxcl12 in mice and used a fibroblast-specific Cre transgene along with various mammary tumor models to...

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Gepubliceerd in:Oncogene
Hoofdauteurs: Ahirwar, Dinesh K., Nasser, Mohd W., Ouseph, Madhu M., Elbaz, Mohamad, Cuitiño, Maria C., Kladney, Raleigh D., Varikuti, Sanjay, Kaul, Kirti, Satoskar, Abhay R., Ramaswamy, Bhuvaneswari, Zhang, Xiaoli, Ostrowski, Michael C., Leone, Gustavo, Ganju, Ramesh K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063845/
https://ncbi.nlm.nih.gov/pubmed/29720724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0263-7
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