Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain

The vagus nerve conveys gastrointestinal cues to the brain to control eating behavior. In obesity, vagally mediated gut-brain signaling is disrupted. Here, we show that the cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide synthesized proportional to the food consumed in vagal a...

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Pubblicato in:Cell Rep
Autori principali: Lee, Shin J., Krieger, Jean-Philippe, Vergara, Macarena, Quinn, Danielle, McDougle, Molly, de Araujo, Alan, Darling, Rebecca, Zollinger, Benjamin, Anderson, Seth, Pan, Annabeth, Simonnet, Emilie J., Pignalosa, Angelica, Arnold, Myrtha, Singh, Arashdeep, Langhans, Wolfgang, Raybould, Helen E., de Lartigue, Guillaume
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063787/
https://ncbi.nlm.nih.gov/pubmed/32049029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.045
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