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Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation

OBJECTIVE: We aimed to identify the role of the enzyme acid sphingomyelinase in the aging of stored units of packed red blood cells (pRBCs) and subsequent lung inflammation after transfusion. SUMMARY BACKGROUND DATA: Large volume pRBC transfusions are associated with multiple adverse clinical sequel...

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Detalhes bibliográficos
Publicado no:Ann Surg
Main Authors: Hoehn, Richard S., Jernigan, Peter L., Japtok, Lukasz, Chang, Alex L., Midura, Emily F., Caldwell, Charles C., Kleuser, Burkhard, Lentsch, Alex B., Edwards, Michael J., Gulbins, Erich, Pritts, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063747/
https://ncbi.nlm.nih.gov/pubmed/28009749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SLA.0000000000001648
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