Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation

OBJECTIVE: We aimed to identify the role of the enzyme acid sphingomyelinase in the aging of stored units of packed red blood cells (pRBCs) and subsequent lung inflammation after transfusion. SUMMARY BACKGROUND DATA: Large volume pRBC transfusions are associated with multiple adverse clinical sequel...

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Dades bibliogràfiques
Publicat a:Ann Surg
Autors principals: Hoehn, Richard S., Jernigan, Peter L., Japtok, Lukasz, Chang, Alex L., Midura, Emily F., Caldwell, Charles C., Kleuser, Burkhard, Lentsch, Alex B., Edwards, Michael J., Gulbins, Erich, Pritts, Timothy A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063747/
https://ncbi.nlm.nih.gov/pubmed/28009749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SLA.0000000000001648
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