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A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis
Pathological activation of TGF-β signaling is universal in fibrosis. Aberrant TGF-β signaling in conjunction with transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic myofibroblasts plays a central role in liver fibrosis. Here we report that the DNA demethylase TET3 is anomalously u...
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| Publié dans: | Cell Rep |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7063678/ https://ncbi.nlm.nih.gov/pubmed/32023451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.12.092 |
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