Aptamer-Functionalized Drug Nanocarrier Improves Hepatocellular Carcinoma toward Normal by Targeting Neoplastic Hepatocytes

Site-specific delivery of chemotherapeutics specifically to neoplastic hepatocytes without affecting normal hepatocytes should be a focus for potential therapeutic management of hepatocellular carcinoma (HCC). The aptamer TLS 9a with phosphorothioate backbone modifications (L5) has not been explored...

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Udgivet i:Mol Ther Nucleic Acids
Main Authors: Chakraborty, Samrat, Dlie, Zewdu Yilma, Chakraborty, Somdyuti, Roy, Somdatta, Mukherjee, Biswajit, Besra, Shila Elizabeth, Dewanjee, Saikat, Mukherjee, Alankar, Ojha, Probir Kumar, Kumar, Vinay, Sen, Ramkrishna
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063179/
https://ncbi.nlm.nih.gov/pubmed/32146417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.01.034
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