MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-X(L) expression

There have been few advances in the treatment of small-cell lung cancer (SCLC) because of the lack of targets. MCL1, a member of the anti-apoptotic BCL-2 family, may be a treatment target in several cancers, including SCLC. However, whether the expression profile of the anti-apoptotic BCL-2 family a...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Yasuda, Yuto, Ozasa, Hiroaki, Kim, Young Hak, Yamazoe, Masatoshi, Ajimizu, Hitomi, Yamamoto Funazo, Tomoko, Nomizo, Takashi, Tsuji, Takahiro, Yoshida, Hironori, Sakamori, Yuichi, Nakajima, Naoki, Menju, Toshi, Yoshizawa, Akihiko, Date, Hiroshi, Hirai, Toyohiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063049/
https://ncbi.nlm.nih.gov/pubmed/32152266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2379-2
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