Full-length human GLP-1 receptor structure without orthosteric ligands

Glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor that plays an important role in glucose homeostasis and treatment of type 2 diabetes. Structures of full-length class B receptors were determined in complex with their orthosteric agonist peptides, however, little is k...

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Udgivet i:Nat Commun
Main Authors: Wu, Fan, Yang, Linlin, Hang, Kaini, Laursen, Mette, Wu, Lijie, Han, Gye Won, Ren, Qiansheng, Roed, Nikolaj Kulahin, Lin, Guangyao, Hanson, Michael A., Jiang, Hualiang, Wang, Ming-Wei, Reedtz-Runge, Steffen, Song, Gaojie, Stevens, Raymond C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062719/
https://ncbi.nlm.nih.gov/pubmed/32152292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14934-5
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