Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Diseases Caused by TTC7A Deficiency

BACKGROUND & AIMS: Mutations in the tetratricopeptide repeat domain 7A gene (TTC7A) cause intestinal epithelial and immune defects. Patients can become immune deficient and develop apoptotic enterocolitis, multiple intestinal atresia, and recurrent intestinal stenosis. The intestinal disease in...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Jardine, Sasha, Anderson, Sierra, Babcock, Stephen, Leung, Gabriella, Pan, Jie, Dhingani, Neel, Warner, Neil, Guo, Conghui, Siddiqui, Iram, Kotlarz, Daniel, Dowling, James J, Melnyk, Roman, Snapper, Scott B, Klein, Christoph, Thiagarajah, Jay R, Muise, Aleixo M
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062591/
https://ncbi.nlm.nih.gov/pubmed/31743734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.11.019
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