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Mutation That Promotes Activation of Trypsinogen Increases Severity of Secretagogue-Induced Pancreatitis in Mice

BACKGROUND & AIMS: Mutations in the human serine protease 1 gene (PRSS1), which encodes cationic trypsinogen, can accelerate its autoactivation and cause hereditary or sporadic chronic pancreatitis. Disruption of the locus that encodes cationic trypsinogen in mice (T7) causes loss of expression...

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Bibliografiske detaljer
Udgivet i:Gastroenterology
Main Authors: Jancsó, Zsanett, Sahin-Tóth, Miklós
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062587/
https://ncbi.nlm.nih.gov/pubmed/31751559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.11.020
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