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Syk degradation restrains plasma cell formation and promotes zonal transitions in germinal centers
Germinal centers (GCs) are sites at which B cells proliferate and mutate their antibody-encoding genes in the dark zone (DZ), followed by affinity-based selection in the light zone (LZ). B cell antigen receptor (BCR) signals induce Syk activation followed by rapid phosphatase-mediated desensitizatio...
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| Publicado no: | J Exp Med |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7062533/ https://ncbi.nlm.nih.gov/pubmed/31873727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191043 |
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