Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

RIPK1 kinase activity has been shown to be essential to driving pyroptosis, apoptosis, and necroptosis. However, here we show a kinase activity–independent role for RIPK1 in these processes using a model of TLR priming in a TAK1-deficient setting to mimic pathogen-induced priming and inhibition. TLR...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Exp Med
Päätekijät: Malireddi, R.K. Subbarao, Gurung, Prajwal, Kesavardhana, Sannula, Samir, Parimal, Burton, Amanda, Mummareddy, Harisankeerth, Vogel, Peter, Pelletier, Stephane, Burgula, Sandeepta, Kanneganti, Thirumala-Devi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Rockefeller University Press 2019
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062518/
https://ncbi.nlm.nih.gov/pubmed/31869420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191644
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