Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature with increased IL-18, IL-1β, caspase-1 activity and ASC speck release (Scambler et al. eLife 2019). Here we show that CFTR modulators down regulate this exaggerated proinflammatory r...

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Bibliographic Details
Published in:eLife
Main Authors: Jarosz-Griffiths, Heledd H, Scambler, Thomas, Wong, Chi H, Lara-Reyna, Samuel, Holbrook, Jonathan, Martinon, Fabio, Savic, Sinisa, Whitaker, Paul, Etherington, Christine, Spoletini, Giulia, Clifton, Ian, Mehta, Anil, McDermott, Michael F, Peckham, Daniel
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2020
Subjects:
Immunology and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062465/
https://ncbi.nlm.nih.gov/pubmed/32118580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54556
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