Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation

Cystic Fibrosis (CF) is a recessive genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR mutations cause dysregulation of channel function with intracellular accumulation of misfolded proteins and endoplasmic reticulum (ER) stress, with activat...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Lara-Reyna, Samuel, Scambler, Thomas, Holbrook, Jonathan, Wong, Chi, Jarosz-Griffiths, Heledd H., Martinon, Fabio, Savic, Sinisa, Peckham, Daniel, McDermott, Michael F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687873/
https://ncbi.nlm.nih.gov/pubmed/31428093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01789
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