Metabolite identification, tissue distribution, excretion and preclinical pharmacokinetic studies of ET-26-HCl, a new analogue of etomidate

ET-26-HCl, a novel anaesthetic agent with promising pharmacological properties, lacks extensive studies on pharmacokinetics and disposition in vitro and in vivo. In this study, we investigated the metabolic stability, metabolite production and plasma protein binding (PPB) of ET-26-HCl along with its...

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Vydáno v:R Soc Open Sci
Hlavní autoři: Yu, Lu, Chen, Xu, Zhang, Wen Sheng, Zheng, Liang, Xu, Wen Wen, Xu, Ming Yu, Jiang, Xue Hua, Wang, Ling
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2020
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062083/
https://ncbi.nlm.nih.gov/pubmed/32257329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.191666
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