Deletion of p16 prevents estrogen deficiency-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence

To investigate whether p16 deletion can prevent osteoporosis caused by estrogen deficiency, we first confirmed that p16 protein expression levels were significantly up-regulated in bony tissue of ovariectomized (OVX) wild-type mice. Eight-week-old wild-type and p16(-/-) mice were then sham-operated...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Am J Transl Res
Egile Nagusiak: Li, Jie, Karim, Muhammad Amin, Che, Hui, Geng, Qinghe, Miao, Dengshun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: e-Century Publishing Corporation 2020
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061825/
https://ncbi.nlm.nih.gov/pubmed/32194914
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