Deletion of p16 prevents estrogen deficiency-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence

To investigate whether p16 deletion can prevent osteoporosis caused by estrogen deficiency, we first confirmed that p16 protein expression levels were significantly up-regulated in bony tissue of ovariectomized (OVX) wild-type mice. Eight-week-old wild-type and p16(-/-) mice were then sham-operated...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Am J Transl Res
Main Authors: Li, Jie, Karim, Muhammad Amin, Che, Hui, Geng, Qinghe, Miao, Dengshun
Format: Artigo
Jezik:Inglês
Izdano: e-Century Publishing Corporation 2020
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061825/
https://ncbi.nlm.nih.gov/pubmed/32194914
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