Deletion of p16 prevents estrogen deficiency-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence

To investigate whether p16 deletion can prevent osteoporosis caused by estrogen deficiency, we first confirmed that p16 protein expression levels were significantly up-regulated in bony tissue of ovariectomized (OVX) wild-type mice. Eight-week-old wild-type and p16(-/-) mice were then sham-operated...

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Detaylı Bibliyografya
Yayımlandı:Am J Transl Res
Asıl Yazarlar: Li, Jie, Karim, Muhammad Amin, Che, Hui, Geng, Qinghe, Miao, Dengshun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: e-Century Publishing Corporation 2020
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061825/
https://ncbi.nlm.nih.gov/pubmed/32194914
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