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Poly(1-vinylimidazole) polyplexes as novel therapeutic gene carriers for lung cancer therapy

The present work explores the ability of poly(1-vinylimidazole) (PVI) to complex small interfering RNA (siRNA) silencing vascular endothelial growth factor (VEGF) and the in vitro efficiency of the formed complexes in A549 lung cancer cells. The polyplex formed was found to exhibit 66% complexation...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Beilstein J Nanotechnol
Hauptverfasser: Kandasamy, Gayathri, Danilovtseva, Elena N, Annenkov, Vadim V, Krishnan, Uma Maheswari
Format: Artigo
Sprache:Inglês
Veröffentlicht: Beilstein-Institut 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061483/
https://ncbi.nlm.nih.gov/pubmed/32190532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjnano.11.26
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