Cholesterol induces CD8(+) T-cell exhaustion in the tumor microenvironment

Tumor-infiltrating T cells often lose their effector function; however, the mechanisms are incompletely understood. We report that cholesterol in the tumor microenvironment induces CD8(+) T-cell expression of immune checkpoints and exhaustion. Tumor tissues enriched with cholesterol and cholesterol...

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Dades bibliogràfiques
Publicat a:Cell Metab
Autors principals: Ma, Xingzhe, Bi, Enguang, Lu, Yong, Su, Pan, Huang, Chunjian, Liu, Lintao, Wang, Qiang, Yang, Maojie, Kalady, Matthew F., Qian, Jianfei, Zhang, Aijun, Gupte, Anisha A., Hamilton, Dale J., Zheng, Chengyun, Yi, Qing
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061417/
https://ncbi.nlm.nih.gov/pubmed/31031094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.04.002
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