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Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells
In the mammalian genome, the clustered protocadherin (cPcdh) locus is a paradigm of stochastic gene expression with the potential to generate a unique cPcdh combination in every neuron. Here, we report a chromatin-based mechanism emerging during the transition from the naive to the primed states of...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Nat Genet |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7061033/ https://ncbi.nlm.nih.gov/pubmed/31740836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0526-4 |
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