Annatto-Derived Tocotrienol Promotes Mineralization of MC3T3-E1 Cells by Enhancing BMP-2 Protein Expression via Inhibiting RhoA Activation and HMG-CoA Reductase Gene Expression

PURPOSE: Annatto-derived tocotrienol (AnTT) has been shown to improve bone formation in animal models of osteoporosis and promote differentiation of pre-osteoblastic cells. However, the mechanism of action of AnTT in achieving these effects is unclear. This study aims to investigate the mechanism of...

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Detaylı Bibliyografya
Yayımlandı:Drug Des Devel Ther
Asıl Yazarlar: Wan Hasan, Wan Nuraini, Chin, Kok-Yong, Abd Ghafar, Norzana, Soelaiman, Ima Nirwana
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Dove 2020
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060796/
https://ncbi.nlm.nih.gov/pubmed/32184566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S224941
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