Microglia are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

Spinal long-term potentiation (LTP) at C-fiber synapses is hypothesized to underlie chronic pain. However, the causal link between spinal LTP and chronic pain is still lacking. Here we report that high frequency stimulation (HFS, 100 Hz, 10 V) of the mouse sciatic nerve reliably induces spinal LTP w...

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Published in:Cell Rep
Main Authors: Zhou, Li-Jun, Peng, Jiyun, Xu, Ya-Nan, Zeng, Wei-Jie, Zhang, Jun, Wei, Xiao, Mai, Chun-Lin, Lin, Zhen-Jia, Liu, Yong, Murugan, Madhuvika, Eyo, Ukpong B., Umpierre, Anthony D., Xin, Wen-Jun, Chen, Tao, Li, Mingtao, Wang, Hui, Richardson, Jason R., Tan, Zhi, Liu, Xian-Guo, Wu, Long-Jun
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060767/
https://ncbi.nlm.nih.gov/pubmed/31242418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.087
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