Microglia are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

Spinal long-term potentiation (LTP) at C-fiber synapses is hypothesized to underlie chronic pain. However, the causal link between spinal LTP and chronic pain is still lacking. Here we report that high frequency stimulation (HFS, 100 Hz, 10 V) of the mouse sciatic nerve reliably induces spinal LTP w...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Zhou, Li-Jun, Peng, Jiyun, Xu, Ya-Nan, Zeng, Wei-Jie, Zhang, Jun, Wei, Xiao, Mai, Chun-Lin, Lin, Zhen-Jia, Liu, Yong, Murugan, Madhuvika, Eyo, Ukpong B., Umpierre, Anthony D., Xin, Wen-Jun, Chen, Tao, Li, Mingtao, Wang, Hui, Richardson, Jason R., Tan, Zhi, Liu, Xian-Guo, Wu, Long-Jun
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060767/
https://ncbi.nlm.nih.gov/pubmed/31242418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.087
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