Microglia are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

Spinal long-term potentiation (LTP) at C-fiber synapses is hypothesized to underlie chronic pain. However, the causal link between spinal LTP and chronic pain is still lacking. Here we report that high frequency stimulation (HFS, 100 Hz, 10 V) of the mouse sciatic nerve reliably induces spinal LTP w...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Zhou, Li-Jun, Peng, Jiyun, Xu, Ya-Nan, Zeng, Wei-Jie, Zhang, Jun, Wei, Xiao, Mai, Chun-Lin, Lin, Zhen-Jia, Liu, Yong, Murugan, Madhuvika, Eyo, Ukpong B., Umpierre, Anthony D., Xin, Wen-Jun, Chen, Tao, Li, Mingtao, Wang, Hui, Richardson, Jason R., Tan, Zhi, Liu, Xian-Guo, Wu, Long-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060767/
https://ncbi.nlm.nih.gov/pubmed/31242418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.087
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