Essential requirement for nicastrin in marginal zone and B-1 B cell development

γ-secretase is an intramembrane protease complex that catalyzes the proteolytic cleavage of amyloid precursor protein and Notch. Impaired γ-secretase function is associated with the development of Alzheimer’s disease and familial acne inversa in humans. In a forward genetic screen of mice with N-eth...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Choi, Jin Huk, Han, Jonghee, Theodoropoulos, Panayotis C., Zhong, Xue, Wang, Jianhui, Medler, Dawson, Ludwig, Sara, Zhan, Xiaoming, Li, Xiaohong, Tang, Miao, Gallagher, Thomas, Yu, Gang, Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060662/
https://ncbi.nlm.nih.gov/pubmed/32071239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916645117
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