Interstitial chromosomal deletion of the tuberous sclerosis complex 2 locus is a signature for radiation‐associated renal tumors in Eker rats

Ionizing radiation can damage DNA and, therefore, is a risk factor for cancer. Eker rats, which carry a heterozygous germline mutation in the tumor‐suppressor gene tuberous sclerosis complex 2 (Tsc2), are susceptible to radiation‐induced renal carcinogenesis. However, the molecular mechanisms involv...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Inoue, Tatsuya, Kokubo, Toshiaki, Daino, Kazuhiro, Yanagihara, Hiromi, Watanabe, Fumiko, Tsuruoka, Chizuru, Amasaki, Yoshiko, Morioka, Takamitsu, Homma‐Takeda, Shino, Kobayashi, Toshiyuki, Hino, Okio, Shimada, Yoshiya, Kakinuma, Shizuko
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060461/
https://ncbi.nlm.nih.gov/pubmed/31925975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14307
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