β(3) Adrenoceptor‐induced cholinergic inhibition in human and rat urinary bladders involves the exchange protein directly activated by cyclic AMP 1 favoring adenosine release

BACKGROUND AND PURPOSE: The mechanism by which β(3) receptor agonists (e.g. mirabegron) control bladder overactivity may involve adenosine release from human and rat detrusor smooth muscle. Retrograde activation of adenosine A(1) receptors reduces ACh release from cholinergic bladder nerves. β(3)‐Ad...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Silva, Isabel, Magalhães‐Cardoso, M. Teresa, Ferreirinha, Fátima, Moreira, Sílvia, Costa, Ana Filipa, Silva, Diogo, Vieira, Cátia, Silva‐Ramos, Miguel, Correia‐de‐Sá, Paulo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060368/
https://ncbi.nlm.nih.gov/pubmed/31721163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14921
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