β(3) Adrenoceptor‐induced cholinergic inhibition in human and rat urinary bladders involves the exchange protein directly activated by cyclic AMP 1 favoring adenosine release

BACKGROUND AND PURPOSE: The mechanism by which β(3) receptor agonists (e.g. mirabegron) control bladder overactivity may involve adenosine release from human and rat detrusor smooth muscle. Retrograde activation of adenosine A(1) receptors reduces ACh release from cholinergic bladder nerves. β(3)‐Ad...

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Publicat a:Br J Pharmacol
Autors principals: Silva, Isabel, Magalhães‐Cardoso, M. Teresa, Ferreirinha, Fátima, Moreira, Sílvia, Costa, Ana Filipa, Silva, Diogo, Vieira, Cátia, Silva‐Ramos, Miguel, Correia‐de‐Sá, Paulo
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060368/
https://ncbi.nlm.nih.gov/pubmed/31721163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14921
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