PO‐322 exerts potent immunosuppressive effects in vitro and in vivo by selectively inhibiting SGK1 activity

BACKGROUND AND PURPOSE: Immunosuppressive drugs have shown great promise in treating autoimmune diseases in recent years. A series of novel oxazole derivatives were screened for their immunosuppressive activity. PO‐322 [1H‐indole‐2,3‐dione 3‐(1,3‐benzoxazol‐2‐ylhydrazone)] was identified as the most...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Br J Pharmacol
Main Authors: Lai, Yi, Luo, Xing‐Yan, Guo, Hui‐Jie, Wang, Si‐Yu, Xiong, Jing, Yang, Shu‐Xia, Li, Li‐Mei, Zou, Qiang, Mo, Chun‐Fen, Wang, Yan‐Tang, Liu, Yang
פורמט: Artigo
שפה:Inglês
יצא לאור: John Wiley and Sons Inc. 2020
נושאים:
Research Papers
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060359/
https://ncbi.nlm.nih.gov/pubmed/31724152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14926
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