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PO‐322 exerts potent immunosuppressive effects in vitro and in vivo by selectively inhibiting SGK1 activity
BACKGROUND AND PURPOSE: Immunosuppressive drugs have shown great promise in treating autoimmune diseases in recent years. A series of novel oxazole derivatives were screened for their immunosuppressive activity. PO‐322 [1H‐indole‐2,3‐dione 3‐(1,3‐benzoxazol‐2‐ylhydrazone)] was identified as the most...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7060359/ https://ncbi.nlm.nih.gov/pubmed/31724152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14926 |
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