Lipid availability determines skeletal progenitor cell fate via SOX9

The avascular nature of cartilage makes it a unique tissue(1–4), but whether and how the absence of nutrient supply regulates chondrogenesis remains unknown. Here, we show that obstruction of vascular invasion during bone healing favours chondrogenic over osteogenic differentiation of skeletal proge...

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Published in:Nature
Main Authors: van Gastel, Nick, Stegen, Steve, Eelen, Guy, Schoors, Sandra, Carlier, Aurélie, Daniëls, Veerle W., Baryawno, Ninib, Przybylski, Dariusz, Depypere, Maarten, Stiers, Pieter-Jan, Lambrechts, Dennis, Van Looveren, Riet, Torrekens, Sophie, Sharda, Azeem, Agostinis, Patrizia, Lambrechts, Diether, Maes, Frederik, Swinnen, Johan V., Geris, Liesbet, Van Oosterwyck, Hans, Thienpont, Bernard, Carmeliet, Peter, Scadden, David T., Carmeliet, Geert
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060079/
https://ncbi.nlm.nih.gov/pubmed/32103177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2050-1
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