Lipid availability determines skeletal progenitor cell fate via SOX9

The avascular nature of cartilage makes it a unique tissue(1–4), but whether and how the absence of nutrient supply regulates chondrogenesis remains unknown. Here, we show that obstruction of vascular invasion during bone healing favours chondrogenic over osteogenic differentiation of skeletal proge...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: van Gastel, Nick, Stegen, Steve, Eelen, Guy, Schoors, Sandra, Carlier, Aurélie, Daniëls, Veerle W., Baryawno, Ninib, Przybylski, Dariusz, Depypere, Maarten, Stiers, Pieter-Jan, Lambrechts, Dennis, Van Looveren, Riet, Torrekens, Sophie, Sharda, Azeem, Agostinis, Patrizia, Lambrechts, Diether, Maes, Frederik, Swinnen, Johan V., Geris, Liesbet, Van Oosterwyck, Hans, Thienpont, Bernard, Carmeliet, Peter, Scadden, David T., Carmeliet, Geert
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060079/
https://ncbi.nlm.nih.gov/pubmed/32103177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2050-1
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