Classification of Type 2 Diabetes Genetic Variants and a Novel Genetic Risk Score Association With Insulin Clearance

CONTEXT: Genome-wide association studies have identified more than 450 single nucleotide polymorphisms (SNPs) for type 2 diabetes (T2D). OBJECTIVE: To facilitate use of these SNPs in future genetic risk score (GRS)-based analyses, we aimed to classify the SNPs based on physiology. We also sought to...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Goodarzi, Mark O, Palmer, Nicholette D, Cui, Jinrui, Guo, Xiuqing, Chen, Yii-Der I, Taylor, Kent D, Raffel, Leslie J, Wagenknecht, Lynne E, Buchanan, Thomas A, Hsueh, Willa A, Rotter, Jerome I
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Clinical Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059988/
https://ncbi.nlm.nih.gov/pubmed/31714576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/clinem/dgz198
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