A novel method for testing association of multiple genetic markers with a multinomial trait

We developed a multinomial probit model with singular value decomposition for testing a large number of single nucleotide polymorphisms (SNPs) simultaneously, using maximum likelihood estimation and permutation. The method was validated by simulation. We simulated 1000 SNPs, including 9 associated w...

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Bibliografske podrobnosti
izdano v:Proc Am Stat Assoc
Main Authors: Kwon, Soonil, Goodarzi, Mark O., Taylor, Kent D., Cui, Jinrui, Chen, Y-D. Ida, Rotter, Jerome I., Hsueh, Willa, Guo, Xiuqing
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4439253/
https://ncbi.nlm.nih.gov/pubmed/26005397
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