Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia

Chimeric antigen receptor (CAR) T cells have radically improved the treatment of B cell–derived malignancies by targeting CD19. The success has not yet expanded to treat acute myeloid leukemia (AML). We developed a Sequentially Tumor-Selected Antibody and Antigen Retrieval (STAR) system to rapidly i...

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Vydáno v:Blood
Hlavní autoři: He, Xin, Feng, Zijie, Ma, Jian, Ling, Sunbin, Cao, Yan, Gurung, Buddha, Wu, Yuan, Katona, Bryson W., O’Dwyer, Kienan P., Siegel, Don L., June, Carl H., Hua, Xianxin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2020
Témata:
Plenary Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059518/
https://ncbi.nlm.nih.gov/pubmed/31951650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002779
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