The Glucagon-Like Peptide-1 Analogue Liraglutide Reduces Seizures Susceptibility, Cognition Dysfunction and Neuronal Apoptosis in a Mouse Model of Dravet Syndrome

Dravet syndrome (DS) is a refractory epilepsy typically caused by heterozygous mutations of the Scn1a gene, which encodes the voltage-gated sodium channel Nav1.1. Glucagon-like peptide-1 (GLP-1) analogues, effective therapeutic agents for the treatment of diabetes, have recently become attractive tr...

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Vydáno v:Front Pharmacol
Hlavní autoři: Liu, Shenhai, Jin, Zhe, Zhang, Yiling, Rong, ShiKuo, He, Wenxin, Sun, Kuisheng, Wan, Din, Huo, Junming, Xiao, Lifei, Li, Xinxiao, Ding, Na, Wang, Feng, Sun, Tao
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059191/
https://ncbi.nlm.nih.gov/pubmed/32184723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00136
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