Development of a methodology to make individual estimates of the precision of liquid chromatography-tandem mass spectrometry drug assay results for use in population pharmacokinetic modeling and the optimization of dosage regimens

BACKGROUND: The clinical value of therapeutic drug monitoring can be increased most significantly by integrating assay results into clinical pharmacokinetic models for optimal dosing. The correct weighting in the modeling process is 1/variance, therefore, knowledge of the standard deviations (SD) of...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Karvaly, Gellért Balázs, Neely, Michael N., Kovács, Krisztián, Vincze, István, Vásárhelyi, Barna, Jelliffe, Roger W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058336/
https://ncbi.nlm.nih.gov/pubmed/32134971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0229873
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