Pharmacokinetics and Tissue Distribution of Combined Triptolide and Paeoniflorin Regimen for Percutaneous Administration in Rats Assessed by Liquid Chromatography-Tandem Mass Spectrometry

Triptolide (TP) has shown potential in rheumatoid arthritis (RA) treatment, but the narrow therapeutic window limits its clinical application. In clinical practice, the compatibility of Tripterygium wilfordii and Paeonia lactiflora is often used to attenuate the toxicity of TP, but its compatibility...

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Detalhes bibliográficos
Publicado no:Evid Based Complement Alternat Med
Main Authors: Guan, Yong-mei, Shen, Qian, He, Liang-fei, Chen, Li-mei, Zang, Zhenzhong, Liu, Lili, Zhu, Wei-feng, Li-hua, Chen, Liu, Hong-ning
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282371/
https://ncbi.nlm.nih.gov/pubmed/34306159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/8864273
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