Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring

BACKGROUND: Pediatric leukemias have a diverse genomic landscape associated with complex structural variants, including gene fusions, insertions and deletions, and single nucleotide variants. Routine karyotype and fluorescence in situ hybridization (FISH) techniques lack sensitivity for smaller geno...

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Detalhes bibliográficos
Publicado no:BMC Med Genomics
Main Authors: Crowgey, Erin L., Mahajan, Nitin, Wong, Wing Hing, Gopalakrishnapillai, Anilkumar, Barwe, Sonali P., Kolb, E. Anders, Druley, Todd E.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057603/
https://ncbi.nlm.nih.gov/pubmed/32131829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-020-0671-8
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